Monday, July 25, 2005

ADA - Fluroide - Bone Cancer

Water Fluoridation and Alleged Risk of Rare Bone Cancer

The Wall Street Journal (July 22, Section B-Market Place, page 1) and other news outlets are reporting that a Harvard University doctor was charged with misrepresenting the findings of a doctoral student's thesis that reportedly found that fluoridated water increases the risk of osteosarcoma (a rare bone cancer). Harvard University is conducting an investigation into the matter. Your local media may report on this story, and your patients may ask you about it. We will post a brief media statement about this issue on ADA.org.

To help you respond to patient inquiries, the ADA provides the following points:

Recent news reports may be alarming people unnecessarily about the safety of water fluoridation.
We're talking about one doctoral student's paper, a paper that has not been published in a scientific journal and therefore has not been available for peer review. Peer review is a process where a group of experts review studies prior to publication to determine if the study is designed well and if the conclusions are valid.
The student notes in her thesis that there are several limitations to her study and recommends that the findings be confirmed using data from other studies. (For example, she notes that the study may not accurately reflect the actual amount of fluoride consumed by study subjects.)
The vast majority of studies by nationally recognized researchers in widely-published, respected and peer-reviewed scientific journals conclude that water fluoridation has not shown any ill effects on health. Studies show that water fluoridation can prevent between 15-40 percent of tooth decay, and that there is no association between cancer rates in humans and optimal levels of fluoride in drinking water.
The Centers for Disease Control and Prevention has proclaimed community water fluoridation one of the 10 greatest public health achievements of the 20th century. According to our current Surgeon General, fluoridation is the single most effective public health measure to prevent tooth decay and to improve oral health for a lifetime, for both children and adults.
Unless and until the weight of scientific evidence shifts to the contrary, the American Dental Association continues to recommend that community water supplies be fluoridated to reduce the risk of tooth decay.
As a dentist, my goal is to help protect and improve your oral health. I believe that water fluoridation is important in preventing tooth decay.
As a member of the American Dental Association, I will be kept up to date on the latest dental research, so if the science on this issue changes, I will certainly let you know immediately.
As the leader of a science-based profession, the ADA is open to new scientific information and welcomes the opportunity to address it according to the standards that prevail in the scientific community.

For more information, go to www.ada.org

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7 Comments:

At 9:47 PM, Anonymous Anonymous said...

Group calls on NIH to remove Harvard professor from fluoride-cancer study


BURLINGTON VT - The Fluoride Action Network (FAN) has urged that a Harvard Professor be removed from a research group studying the association between fluoride and osteosarcoma because his objectivity and ethics are disputed and he has ties to a company that profits from fluoride. FAN also urges other steps be taken to ensure this study meets the highest standards of scientific integrity.

In June, the Environmental Working Group (EWG) charged Chester Douglass, a professor at Harvard and editor of Colgate’s oral health newsletter, with suppressing research linking fluoridation to osteosarcoma, a rare but frequently fatal form of bone cancer. (1) Douglass remains central to the ongoing project.

In a letter sent to Dr. Elias A. Zerhouni, the Director of the National Institutes of Health (NIH), FAN requests that Douglass be replaced with a scientist who is independent of the fluoridation debate, and has no other conflict of interest. (2) FAN also requests the NIH make the data of the $1.3 million taxpayer-funded study freely available for full independent review.

EWG recently issued an ethics complaint against Douglass for misrepresenting his doctoral student's successful dissertation linking fluoridation to osteosarcoma. (3)

Elise Bassin, Douglass' doctoral student, analyzed data collected from U.S. hospitals in the early 1990s by a team of scientists led by Douglass and funded by NIH. In her case-control study, Bassin found that males exposed to fluoridated water during their "mid-childhood growth spurt" (ages 6 to 8) had a significantly increased risk of later developing osteosarcoma. Bassin described the findings as "remarkably robust." (4)

Bassin's dissertation, completed in May 2001 but unpublished and unknown prior to FAN obtaining a copy earlier this year, was recently sent to several expert reviewers by a Wall Street Journal science writer. The reviewers found it to be of "publishable quality." The head of oral health at the CDC, and fluoridation supporter, William Maas said, "She did great shoe-leather epidemiology." (5) According to EWG, Bassin's work "is the most rigorous study of the link between bone cancer and fluoride in tap water ever conducted in the United States." (6)

Prior to the discovery of Bassin's results, the only information available on Douglass' research was a very brief summary published in 1995 in the Journal of Dental Research where Douglass reported no link between fluoridation and bone cancer. (7) Despite assurances by Douglass that a more comprehensive analysis of his data would be forthcoming, Douglass never published the study.

"It's been 10 years now, and Douglass has yet to publish the findings of his first study," says Paul Connett, PhD, Executive Director of FAN. "Now that we know what his data showed, Douglass' failure to disclose these findings is deeply troubling. It will simply not be possible for us or the general public to have confidence in any further work he produces on this matter."

Summarizing Connett says, “With lives at risk and the public's trust at stake, the NIH cannot afford anything less than to secure scrupulous scientific integrity on this study. We are asking that NIH do three things: 1) remove Douglass from the study; 2) demonstrate that none of the other study members has any other conflict of interest or ties to the government's fluoridation program, and, 3) make the data of the study, not just the conclusions, available for independent analysis and review.”

Contact:

Paul Connett, PhD
Executive Director, Fluoride Action Network
Email: paul@fluoridealert.org


References:

(1) Washington Post, "Professor at Harvard is Being Investigated," July 13, 2005.
http://www.washingtonpost.com/wp-dyn/content/article/2005/07/12/AR2005071201277.html

(2) http://www.fluoridealert.org/letter-to-NIH.htm


(3) Environmental Working Group, "Harvard Fluoride Findings Misrepresented?" July 13, 2005. http://www.ewg.org/issues/fluoride/20050627/index.php


(4) Bassin EB. (2001). Association Between Fluoride in Drinking Water During Growth and Development and the Incidence of Ostosarcoma for Children and Adolescents. Doctoral Thesis, Harvard School of Dental Medicine. http://www.fluoridealert.org/health/cancer/bassin-2001.pdf


(5) Wall Street Journal, "Fluoridation, Cancer: Did Researchers Ask the Right Questions?" July 22, 2005.
http://www.fluoridealert.org/news/2323.html


(6) http://ewg.org/issues_content/fluoride/20050627/pdf/ltr_strother_20050627.pdf


(7) Journal of Dental Research 1995; Volume 74, Page 98.
http://www.fluoridealert.org/images/douglass-1995.gif



SOURCE:


Fluoride Action Network http://www.fluoridealert.org
PO Box 5111
Burlington, Vermont 05402

 
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